BP 605 T. PHARMACEUTICAL BIOTECHNOLOGY (Theory) Hand Written Notes.
Scope:
BP 605 T. PHARMACEUTICAL BIOTECHNOLOGY (Theory)
Biotechnology has a long promise to revolutionize the biological sciences and
technology. Scientific application of biotechnology in the field of genetic engineering, medicine and fermentation technology makes the subject interesting. Biotechnology is leading to new biological revolutions in diagnosis, prevention
and cure of diseases, new and cheaper pharmaceutical drugs. Biotechnology has already produced transgenic crops and animals and the future promises lot more. It is basically a research-based subject.
Objectives: Upon completion of the subject student shall be able to;
- Understanding the importance of Immobilized enzymes in Pharmaceutical
Industries - Genetic engineering applications in relation to production of pharmaceuticals
- Importance of Monoclonal antibodies in Industries
- Appreciate the use of microorganisms in fermentation technology
Unit I
a) Brief introduction to Biotechnology with reference to Pharmaceutical Sciences.
b) Enzyme Biotechnology- Methods of enzyme immobilization and applications.
c) Biosensors- Working and applications of biosensors in Pharmaceutical Industries.
d) Brief introduction to Protein Engineering. e) Use of microbes in industry. Production of Enzymes- General consideration – Amylase, Catalase, Peroxidase, Lipase, Protease, Penicillinase. f) Basic principles of genetic engineering.
Unit II
a) Study of cloning vectors, restriction endonucleases and DNA ligase. b) Recombinant DNA technology. Application of genetic engineering in medicine. c) Application of r DNA technology and genetic engineering in the production of: i) Interferon ii) Vaccines- hepatitis- B iii) Hormones-Insulin. d) Brief introduction to PCR.
Unit III
Types of immunity- humoral immunity, cellular immunity a) Structure of Immunoglobulins b) Structure and Function of MHC
c) Hypersensitivity reactions, Immune stimulation and Immune suppressions. d) General method of the preparation of bacterial vaccines, toxoids, viral vaccine, antitoxins, serum-immune blood derivatives and other products relative to immunity. e) Storage conditions and stability of official vaccines f) Hybridoma technology- Production, Purification and Applications g) Blood products and Plasma Substituties.
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