BP 304 T. PHARMACEUTICAL ENGINEERING Hand Written Notes.
Scope: This course is designed to impart a fundamental knowledge on the art and science
of various unit operations used in pharmaceutical industry. Objectives: Upon completion of the course student shall be able:
- To know various unit operations used in Pharmaceutical industries.
- To understand the material handling techniques.
- To perform various processes involved in pharmaceutical manufacturing process.
- To carry out various test to prevent environmental pollution.
- To appreciate and comprehend significance of plant lay out design for optimum
use of resources. - To appreciate the various preventive methods used for corrosion control in
Pharmaceutical industries.
UNIT-I
Flow of fluids: Types of manometers, Reynolds number and its significance, Bernoulli’s theorem and its applications, Energy losses, Orifice meter, Venturimeter, Pitot tube and Rotometer.
Size Reduction: Objectives, Mechanisms & Laws governing size reduction,
factors affecting size reduction, principles, construction, working, uses, merits and
demerits of Hammer mill, ball mill, fluid energy mill, Edge runner mill & end
runner mill.
Size Separation: Objectives, applications & mechanism of size separation,
official standards of powders, sieves, size separation Principles, construction,
working, uses, merits and demerits of Sieve shaker, cyclone separator, Air
separator, Bag filter & elutriation tank.
Download Here Unit-1-Pharmaceutical-Engineering
UNIT-II
Heat Transfer: Objectives, applications & Heat transfer mechanisms. Fourier’s
law, Heat transfer by conduction, convection & radiation. Heat interchangers &
heat exchangers.
Evaporation: Objectives, applications and factors influencing evaporation,
differences between evaporation and other heat process. principles, construction,
working, uses, merits and demerits of Steam jacketed kettle, horizontal tube
evaporator, climbing film evaporator, forced circulation evaporator, multiple
effect evaporator& Economy of multiple effect evaporator. Distillation: Basic Principles and methodology of simple distillation,flash
distillation, fractional distillation, distillation under reduced pressure, steam
distillation & molecular distillation.
Download Here Unit-2-Engineering-Heat-transfer-1
UNIT- III
Drying: Objectives, applications & mechanism of drying process, measurements
& applications of Equilibrium Moisture content, rate of drying curve. principles,
construction, working, uses, merits and demerits of Tray dryer, drum dryer spray
dryer, fluidized bed dryer, vacuum dryer, freeze dryer. Mixing: Objectives, applications & factors affecting mixing, Difference between
solid and liquid mixing, mechanism of solid mixing, liquids mixing and
semisolids mixing. Principles, Construction, Working, uses, Merits and Demerits
of Double cone blender, twin shell blender, ribbon blender, Sigma blade mixer,
planetary mixers, Propellers, Turbines, Paddles & Silverson Emulsifier.
Download Here engineering-Unit-3rd
UNIT-IV
Filtration: Objectives, applications, Theories & Factors influencing filtration,
filter aids, filter medias. Principle, Construction, Working, Uses, Merits and
demerits of plate & frame filter, filter leaf, rotary drum filter, Meta filter &
Cartridge filter, membrane filters and Seidtz filter. Centrifugation: Objectives, principle & applications of Centrifugation,
principles, construction, working, uses, merits and demerits of Perforated basket
centrifuge, Non-perforated basket centrifuge, semi continuous centrifuge & super
centrifuge.
Download Here Unit-4-Pharmaceutical-Engineering
UNIT- V
Materials of pharmaceutical plant construction, Corrosion and its
prevention: Factors affecting during materials selected for Pharmaceutical plant
construction, Theories of corrosion, types of corrosion and there prevention.
Ferrous and nonferrous metals, inorganic and organic non metals, basic of
material handling systems.
Download here engineering-Unit-5th