notes

BP401T. PHARMACEUTICAL ORGANIC CHEMISTRY –III (Theory) Hand Written Notes

BP401T. PHARMACEUTICAL ORGANIC CHEMISTRY –III (Theory) Hand Written Notes

Scope: This subject imparts knowledge on stereo-chemical aspects of organic compounds
and organic reactions, important named reactions, chemistry of important hetero cyclic
compounds. It also emphasizes on medicinal and other uses of organic compounds.
Objectives: At the end of the course, the student shall be able to.

  1. understand the methods of preparation and properties of organic compounds
  2. explain the stereo chemical aspects of organic compounds and stereo chemical
    reactions
  3. know the medicinal uses and other applications of organic compounds

UNIT-I
Stereo isomerism
Optical isomerism – Optical activity, enantiomerism, diastereoisomerism, meso compounds
Elements of symmetry, chiral and achiral molecules
DL system of nomenclature of optical isomers, sequence rules, RS system of
nomenclature of optical isomers
Reactions of chiral molecules
Racemic modification and resolution of racemic mixture. Asymmetric synthesis: partial and absolute.

Download Here Unit-1st-Organic-chemistry-4th-sem

 

UNIT-II
Geometrical isomerism
Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems)
Methods of determination of configuration of geometrical isomers.
Conformational isomerism in Ethane, n-Butane and Cyclohexane. Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical
activity. Stereospecific and stereoselective reactions.

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UNIT-III
Heterocyclic compounds:
Nomenclature and classification
Synthesis, reactions and medicinal uses of following compounds/derivatives
Pyrrole, Furan, and Thiophene
Relative aromaticity and reactivity of Pyrrole, Furan and Thiophene.

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UNIT-IV 
Synthesis, reactions and medicinal uses of following compounds/derivatives
Pyrazole, Imidazole, Oxazole and Thiazole.
Pyridine, Quinoline, Isoquinoline, Acridine and Indole. Basicity of pyridine
Synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives.

Download Here unit-4th-Organic-chemistry-4th-sem

 

UNIT-V 
Reactions of synthetic importance
Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch
reduction, Wolff Kishner reduction.
Oppenauer-oxidation and Dakin reaction.
Beckmanns rearrangement and Schmidt rearrangement.
Claisen-Schmidt condensation.

Download Here Unit-5th-Organic-Chemistry

 

Physical Pharmacy MCQ

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