BP202T. PHARMACEUTICAL ORGANIC CHEMISTRY – 1 handwritten Notes
Scope: This subject deals with the classification and nomenclature of simple organic
compounds, structural isomerism, intermediates forming in reactions, important physical
properties, reactions, and methods of preparation of these compounds. The syllabus also
emphasizes mechanisms and orientation of reactions.
Classification, nomenclature, and isomerism
Classification of Organic Compounds
Common and IUPAC systems of nomenclature of organic compounds
(up to 10 Carbons open chain and carbocyclic compounds)
Structural isomerisms in organic compounds.
Alkanes*, Alkenes* and Conjugated dienes*
SP3 hybridization in alkanes, Halogenation of alkanes, use of paraffin.
Stabilities of alkenes, SP2 hybridization in alkenes
E1 and E2 reactions – kinetics, order of reactivity of alkyl halides, rearrangement of
carbocations, Saytzeffs orientation, and evidence. E1 versus E2 reactions, Factors affecting E1
and E2 reactions. Ozonolysis, electrophilic addition reactions of alkenes, Markownikoff’s
orientation, free radical addition reactions of alkenes, Anti Markownikoff’s orientation.
Stability of conjugated dienes, Diel-Alder, electrophilic addition, free radical addition
reactions of conjugated dienes, allylic rearrangement.
Alkyl halides*
SN1 and SN2 reactions – kinetics, order of reactivity of alkyl halides, stereochemistry and
rearrangement of carbocations.
SN1 versus SN2 reactions, Factors affecting SN1 and SN2 reactions
Structure and uses of ethyl chloride, Chloroform, trichloroethylene, tetrachloroethylene, dichloromethane, tetrachloromethane, and iodoform. Alcohols*- Qualitative tests, Structure, and uses of Ethyl alcohol, Methyl alcohol,
chlorobutanol, Cetosteryl alcohol, Benzyl alcohol, Glycerol, Propylene.
Unit-3rd-for-organic-chemistry
Carbonyl compounds* (Aldehydes and ketones)
Nucleophilic addition, Electromeric effect, aldol condensation, Crossed Aldol condensation,
Cannizzaro reaction, Crossed Cannizzaro reaction, Benzoin condensation, Perkin
condensation, qualitative tests, Structure, and uses of Formaldehyde, Paraldehyde, Acetone,
Chloral hydrate, Hexamine, Benzaldehyde, Vanillin, Cinnamaldehyde.
Carboxylic acids*
The acidity of carboxylic acids, effect of substituents on acidity, inductive effect, and qualitative
tests for carboxylic acids , amide and ester
Structure and Uses of Acetic acid, Lactic acid, Tartaric acid, Citric acid, Succinic acid. Oxalic
acid, Salicylic acid, Benzoic acid, Benzyl benzoate, Dimethyl phthalate, Methyl salicylate and
Acetyl salicylic acid
Aliphatic amines* – Basicity, the effect of substituent on Basicity. Qualitative test, Structure, and uses of Ethanolamine, Ethylenediamine, Amphetamine.