BP401T. PHARMACEUTICAL ORGANIC CHEMISTRY –III Hand Written Notes
BP401T. PHARMACEUTICAL ORGANIC CHEMISTRY –III Hand Written Notes. Scope: This subject imparts knowledge on stereo-chemical aspects of organic compounds
and organic reactions, important named reactions, chemistry of important hetero cyclic
compounds. It also emphasizes on medicinal and other uses of organic compounds.
UNIT-I
Stereo isomerism
Optical isomerism – Optical activity, enantiomerism, diastereoisomerism, meso compounds
Elements of symmetry, chiral and achiral molecules
DL system of nomenclature of optical isomers, sequence rules, RS system of
nomenclature of optical isomers
Reactions of chiral molecules
Racemic modification and resolution of racemic mixture. Asymmetric synthesis: partial and absolute.
Unit-1st-Organic-chemistry-4th-sem
UNIT-II
Geometrical isomerism
Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems)
Methods of determination of configuration of geometrical isomers.
Conformational isomerism in Ethane, n-Butane and Cyclohexane. Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical
activity. Stereospecific and stereoselective reactions.
unit-2-organic-chemistry-4th-sem
UNIT-III
Heterocyclic compounds:
Nomenclature and classification
Synthesis, reactions and medicinal uses of following compounds/derivatives
Pyrrole, Furan, and Thiophene
Relative aromaticity and reactivity of Pyrrole, Furan and Thiophen.
unit-3rd-organic-chemistry-4th-sem
UNIT-IV
Synthesis, reactions and medicinal uses of following compounds/derivatives
Pyrazole, Imidazole, Oxazole and Thiazole.
Pyridine, Quinoline, Isoquinoline, Acridine and Indole. Basicity of pyridine
Synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives.
unit-4th-Organic-chemistry-4th-sem
UNIT-V
Reactions of synthetic importance
Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch
reduction, Wolff Kishner reduction.
Oppenauer-oxidation and Dakin reaction.
Beckmanns rearrangement and Schmidt rearrangement.
Claisen-Schmidt condensatio.